Pharmacokinetic studies are essential yet demanding, typically relying on expensive proprietary software for Non-Compartmental Analysis (NCA). aNCA is an alternative developed collaboratively by Roche, Lucid Analytics, Appsilon, and Human Predictions. It is being developed within Pharmaverse, aiming to become a worldwide standard by utilizing open source development to make the process more efficient, economical, and transparent. The app performs an end-to-end approach, using interactive plots for data exploration, half life customization, TLGs, and report generation.
aNCA is planned to be released on CRAN soon. It currently reaches 100% of testing coverage on its functions and has successfully passed internal package validations.
aNCA uses PKNCA, a widely used package that calculates over 200 PK parameters, has been tested against other industry-standard NCA software, showing differences within +/-0.1% for most tested parameters.

We aim to present aNCA, highlight its innovative software concepts, discuss how we tackled key challenges, and showcase how open source and Shiny achieve industry-standard PK software. However, we welcome suggestions on focus areas for the R/Pharma audience.
Gerardo Jose Rodriguez | Jana Spinner
Lucid Analytics | Lucid Analytics
Implementing an end-to-end NCA software using Shiny
Pharmacokinetic studies are essential yet demanding, typically relying on expensive proprietary software for Non-Compartmental Analysis (NCA). aNCA is an alternative developed collaboratively by Roche, Lucid Analytics, Appsilon, and Human Predictions. It is being developed within Pharmaverse, aiming to become a worldwide standard by utilizing open source development to make the process more efficient, economical, and transparent. The app performs an end-to-end approach, using interactive plots for data exploration, half life customization, TLGs, and report generation. aNCA is planned to be released on CRAN soon. It currently reaches 100% of testing coverage on its functions and has successfully passed internal package validations. aNCA uses PKNCA, a widely used package that calculates over 200 PK parameters, has been tested against other industry-standard NCA software, showing differences within +/-0.1% for most tested parameters.  We aim to present aNCA, highlight its innovative software concepts, discuss how we tackled key challenges, and showcase how open source and Shiny achieve industry-standard PK software. However, we welcome suggestions on focus areas for the R/Pharma audience.